BRCA Mutation Database

Through collaborations with the Huntsman Cancer Institute (HCI), and with the WHO International Agency for Research on Cancer (IARC), the University of Utah Department of Pathology and ARUP Laboratories are pleased to host the BRCA mutation database.

The purpose of this database is to provide information on BRCA1 and BRCA2 gene mutations and their impact on risk of developing breast cancer, ovarian cancer and certain other cancers.

Two types of databases are provided. One is a list of mutations curated from critical review of literature and family studies. The other provides in silico prediction of risk to help understand variants of unknown significance. Watch Dr. Tavtigian introductory talk. [15 min video]

Two genes (BRCA1 and BRCA2) are curated separately. The two databases mentioned above are available for both genes. Go to the landing pages for either gene with the buttons below.