Light Chain Testing in Myelomas and MGUS’s
Monoclonal gammopathies are diagnosed by a triad of criteria including clinical symptoms of the disease, bone marrow analysis and clinical laboratory testing. Protein electrophoresis and immunofixation in serum and urine are the most common tests in clinical laboratory for diagnosis of monoclonal gammopathies. More recently, serum free light chain testing has become an important tool for diagnosis and prognosis of these conditions. The indications and limitation of these clinical laboratory tests are reviewed in this presentation.
Originally presented February 07, 2013 in Park City, Utah.
Julio Delgado, MD, MS
Medical Director, Protein Immunology Laboratory, ARUP Laboratories
Medical Director, Immunogenetics Laboratory, ARUP Laboratories
Group Medical Director, Immunology Division, ARUP Laboratories
Associate Professor of Pathology, University of Utah School of Medicine
Dr. Delgado is the medical director of the Protein Immunology and Immunogenetics laboratories and group medical director of the Immunology Division at ARUP, as well as an associate professor of pathology at the University of Utah School of Medicine. Dr. Delgado received his MD from Universidad Industrial de Santander in Colombia and his MS degree in epidemiology from the Harvard School of Public Health, completing both his clinical residency training in clinical pathology and his research fellowship in immunology at the Harvard Medical School. He is board certified in clinical pathology and histocompatibility laboratory testing by the American Board of Pathology and the American Board of Histocompatibility and Immunogenetics.
After this presentation, participants will be able to:
- Discuss the classification and diagnostic criteria of monoclonal gammopathies.
- Describe clinical laboratory testing for diagnosis and monitoring of monoclonal gammopathies.
- Review clinical indications of free light chain testing.
University of Utah School of Medicine, University of Utah Department of Pathology, and ARUP Laboratories